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Mitochondria

Protein responsible for rare childhood disorder gives clues to common neurodegenerative conditions

1 Jul 2015, 11:35 a.m.

A new protein that appears to play a role in mitochondrial disease – a rare condition where a lack of energy in cells means that they can’t function properly – could prove to be important in conditions such as Alzheimer’s, Parkinson’s and Huntington’s dis

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Archived tumour samples

The 100-year-old tumours pinpointing the genetic causes of cancer

22 May 2017, 3:44 p.m.

A collection of century old tumour samples held at Great Ormond Street Hospital (GOSH) has helped shed light on the genetic mutations that cause some of the rarest childhood cancers.

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GOSH patient with a research nurse

​GOSH ranked fourth in North Thames region for clinical trial activity

2 Aug 2017, 1:33 p.m.

Great Ormond Street Hospital for Children NHS Foundation Trust (GOSH) has been ranked 4th in the North Thames region for number of active clinical research studies in 2016/17, in figures released today by the National Institute for Health Research (NIHR).

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Inside the Clinical Research Facility

21 Sep 2017, 9:40 a.m.

Walk down to Level 1 of the Frontage Building, and you'll discover the National Institute for Health Research (NIHR) Great Ormond Street Clinical Research Facility (CRF). This bright and colourful purpose-built centre provides a specialist ward area for c

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Researcher Elisa Cuevas in the iPSC facility at GOSH/ICH

Boost for stem cell research at GOSH

21 Nov 2017, 11:30 a.m.

A state-of-the-art stem cell research facility is now open at Great Ormond Street Hospital (GOSH), increasing our capacity for cutting edge research into regenerative medicine.

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A patient and her mum in the CRF

A picture of research

18 May 2018, 2:32 p.m.

A whole team of people carry out research in Great Ormond Street Hospital. To thank them all on this International Clinical Trials Day, we’re sharing a picture drawn by one of the patients being seen.

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New drug halves hearing loss in children following cancer treatment

20 Jun 2018, 11:56 a.m.

Giving the drug sodium thiosulphate after chemotherapy reduces hearing loss in children treated for liver cancer, according to findings published in the New England Journal of Medicine today (Wednesday).

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Patient in policeman's uniform

Living with epilepsy – TJ’s story

26 Jul 2018, 4:34 p.m.

TJ is 14 and lives with his mum Janet, dad Kevin and brother Casey, 21 in Northamptonshire, a lot of TJ’s short life has been spent in and out of hospital.

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EEG

Publication success for four clinical trials

25 Jul 2018, 2:44 p.m.

Four collaborative research trials, which all included GOSH patients treated at the National Institute for Health Research (NIHR) GOSH Clinical Research Facility (CRF), have been recently published in the prestigious New England Journal of Medicine.

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Guests at the DRIVE Opening Event, October 2018

Opening our new digital hub for healthcare

11 Oct 2018, 12:28 p.m.

Last night we launched DRIVE – Digital Research, Informatics and Virtual Environments – a digital hub set to transform the use of technology in healthcare and improve patient outcomes at Great Ormond Street Hospital (GOSH) and beyond.

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GOSH team reveals the world’s first functional tissue engineered oesophagus

16 Oct 2018, 3:18 p.m.

Researchers have grown the world’s first oesophagus engineered from stem cells and successfully transplanted them into mice, in a pioneering new study led by Great Ormond Street Hospital (GOSH) and the UCL Great Ormond Street Institute of Child Health (IC

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Mr Dominic Thompson, Consultant Neurosurgeon

First UK surgery in the womb for baby with spina bifida

24 Oct 2018, 12:01 a.m.

A team from Great Ormond Street Hospital (GOSH) and University College London Hospitals (UCLH) have carried out the first two operations on the damaged spinal cords of babies in the womb, in what are the first surgeries of their kind in the UK.

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Sterile GOSgene laboratory

GOSH to be first in UK to offer groundbreaking cancer therapy

27 Nov 2018, 8:51 a.m.

Great Ormond Street Hospital (GOSH) is to become the first hospital in the UK to offer a pioneering cancer therapy, known as CAR-T therapy, to NHS patients with B-cell acute lymphoblastic leukaemia (ALL). The first patients begin treatment at GOSH this we

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Dr Sara Ghorashian, Consultant Haematologist at GOSH

'Training' viruses to kill cancer

27 Nov 2018, 2:45 p.m.

Great Ormond Street Hospital (GOSH) is to become the first hospital in the UK to offer a pioneering cancer therapy, known as CAR-T therapy, to NHS patients with an aggressive blood cancer called B-cell acute lymphoblastic leukaemia.

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Camelia Botnar Labs

A year of research at GOSH

23 Dec 2018, 9 a.m.

A whole host of exciting scientific discoveries have been made at Great Ormond Street Hospital (GOSH) and the UCL Institute of Child Health (ICH). We’re unwrapping our biggest discoveries from the last 12 months.

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GOSH hosts celebration for Year of Zayed

21 Dec 2018, 10:50 a.m.

In celebration of the Year of Zayed, Great Ormond Street Hospital (GOSH) and the UCL Great Ormond Street Institute of Child Health (ICH) welcomed a delegation from the Government of Abu Dhabi this week. This year celebrates 100 years since the birth of th

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Photographer: Paul Wilson photography

GOSH’s groundbreaking gene therapy research to feature in Royal Institution Christmas Lectures

28 Dec 2018, 10:25 a.m.

Professor Bobby Gaspar, who has pioneered gene therapy research at Great Ormond Street Hospital (GOSH) for the last 20 years, was a special guest at the Royal Institution Christmas lectures this year.

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Yuvan receiving CAR-T cell therapy

GOSH patient first to receive ground-breaking new cancer therapy on the NHS

31 Jan 2019, 10:15 a.m.

An 11-year-old boy has become the first NHS patient to receive a pioneering new cancer therapy at Great Ormond Street Hospital (GOSH).

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A teenager with brown hair, a purple top and jeans, has a blood pressure monitor on her arm. There is a male nurse with brown hair and a grey shirt sitting next to her and a blue and white robot on the desk in front of them.

Young people shaping healthcare technology research

29 Apr 2019, 3:19 p.m.

Twenty five young people came to Great Ormond Street Hospital’s (GOSH) new digital hub DRIVE last week as part of an event to help digital researchers and industry engage with a diverse group of young people and hear how their products could be improved t

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International Clinical Trials Day – Meet Matei

20 May 2019, 9:59 a.m.

To mark International Clinical Trials Day this May, we took a visit to the Clinical Research Facility (CRF) to meet with GOSH mum Flavia, whose son Matei has been on a clinical trial at the hospital for the last couple of years.

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