Lactate or pyruvate disorders: lactate/Pyruvate ratio

EPIC

BLAPY

Section

Chemical Pathology - Routine Laboratory

Clinical indications

Pyruvate is measured with lactate to assist in the differential diagnosis of lactic acidosis. The lactate/pyruvate ratio reflects the cytoplasmic NADH/NAD ratio which is raised in respiratory chain disorders as opposed to other causes of lactic acidosis

Specimen requirement

perchloric acid precipitation (see user guide for protocol)

Dispatch and handling instructions

Freeze immediately. Send frozen.

Turnaround time

1 to 2 weeks

Synonym

Not applicable

Is it IS0 15189 accredited?

Yes