Granule release assay

Granule release assay

Immunology

Tests the ability of T and NK cells to degranulate in response to a stimulus and express CD107a on their surface. Screens the pathway that includes syntaxin 11 and Munc13 to 4/18-2, lyst and Rab27a

10mls EDTA plus a healthy control sample. Plesae send 1ml extra EDTA for DNA storage

This is a 2 day assay. Samples sent on a Friday may need repeating if results are abnormal. Where possible send Mon-Thurs only. Samples should be less than 24 hours old. This test should only be undertaken under the direction of a Consultant Immunologist/ Senior Clinical Scientist. External referrals must be discussed with Dr Kimberly Gilmour (020 7813 8466) or her deputy and accompanied by a completed referral form (available on website)

5 days

Not applicable

Yes