https://www.gosh.nhs.uk/wards-and-departments/departments/clinical-specialties/immunology-information-parents-and-visitors/conditions-we-treat/
Conditions treated by the Immunology department
Conditions treated by the Immunology department at Great Ormond Street Hospital (GOSH) include:
Severe immunodeficiencies for which stem cell transplantation or gene therapy may be appropriate
- severe combined immunodeficiency (SCID) (all forms)*
- other (as yet molecularly undefined) combined immunodeficiencies
- X-linked hyper-IgM syndrome (CD40 ligand deficiency)
- Wiskott Aldrich syndrome
- X-linked lymphoproliferative syndrome
- haemophagocytic lymphohistiocytosis
- chronic granulomatous disease
- Chediak-Higashi syndrome
- leucocyte adhesion deficiencies
*All infants affected by SCID require corrective therapy. For all other disorders each child is individually assessed regarding the need for transplantation/gene therapy.
Primary immunodeficiencies not requiring transplantation
- common variable immunodeficiency (CVID)
- X-linked agammaglobulinemia (XLA)
- transient hypogammaglobulinemia of infancy
- selective IgA deficiency
- IgG subclass deficiency (usually associated with IgA deficiency)
- C1 esterase inhibitor deficiency (hereditary angioedema)
- hyper-IgE syndrome (Job’s syndrome)
- other neutrophil disorders
- ataxia telangiectasia
Other immunological disorders
- periodic fever syndromes
- vasculitis
- autoimmune lymphoproliferative syndrome
Management guidelines
A range of management guidelines have been prepared by the UK-Primary Immunodeficiency Network.