https://www.gosh.nhs.uk/wards-and-departments/departments/clinical-specialties/anaesthesia-information-parents-and-visitors/research-and-publications/

Research and publications from the Anaesthesia department

The Anaesthesia Department is involved in a broad range of research. Current themes are listed below.

Research

Current themes include:

Anaesthesia and cardiac anaesthesia

total intra-venous anaesthesia for short painful procedures

cleft lip and palate surgery including international delivery of services

respiratory effects of drugs

assessment of induction drugs

cardiac bypass anaesthesia

pulmonary hypertension

Sedation

We have a unique interest in developing safe and effective sedation, focusing in particular on nurse-led sedation and sedation for patients undergoing chest drain removal and endoscopy.

Anxiety management

We are looking at helping reduce anxiety in children undergoing anaesthesia, in particular effective training in behavioural modification and management techniques, identification of anxious children and management of severe anxiety.

Resuscitation

We have developed and supported the training of paediatric resuscitation at Great Ormond Street Hospital, in the UK and abroad. We are studying in particular peri-operative intravenous fluids, choice of crystalloid and major haemorrhage.

Airway management

Our patient population allow us to perfect techniques for training in airway management, in particular developing and teaching skills and assessment of new techniques.

Assessing new technology

Another focus is assessment of new technology. We are developing a record of cooperation with industry looking at temperature control, continuous non invasive blood pressure, continuous non-invasive haemoglobin estimation and continuous trans-cutaneous CO2 monitoring.

Safety

We are interested in improving safety by developing systems for teams including handover to intensive care, crisis management using simulators, implementation of World Health Organisation surgical protocols and assessment of theatre checklists.

Publications

Reference 1

de Beer D, Bingham R (2011) The child with facial abnormalities. Curr Opin Anaesthesiol 24 (3): 282-8

Reference 2

Bajaj Y, Tweedie D, Ifeacho S, Hewitt R, Lloyd-Thomas A, Albert DM (2011) Single stage laryngotracheal reconstruction using endoscopic posterior grafting in isolated posterior glottic stenosis in children - How we do it. Int J Pediatr Otorhinolaryngol Feb: 27

Reference 3

Bishay M, Giacomello L, Retrosi G, Thyoka M, Nah SA, McHoney M, De Coppi P, Brierley J, Scuplak S, Kiely EM, Curry JI, Drake DP, Cross KM, Eaton S, Pierro A (2011) Decreased cerebral oxygen saturation during thoracoscopic repair of congenital diaphragmatic hernia and esophageal atresia in infants. J Pediatr Surg 46 (1): 47-51

Reference 4

Walker IA, Newton M, Bosenberg AT (2011) Improving surgical safety globally: pulse oximetry and the WHO Guidelines for Safe Surgery. Paediatr Anaesth 21 (7): 825-8

Reference 5

Sury M, Bullock I, Rabar S, Demott K, Guideline Development Group (2010) Sedation for diagnostic and therapeutic procedures in children and young people: summary of NICE guidance. BMJ 341 (): c6819

Reference 6

Walker IA, Obua AD, Mouton F, Ttendo S, Wilson IH (2010) Paediatric surgery and anaesthesia in south-western Uganda: a cross-sectional survey. Bull World Health Organ 88 (12): 897-906

Reference 10

Nandi R, Howard R (2010) Anesthesia and epidermolysis bullosa. Dermatol Clin 28 (2): 319-24, x

Reference 11

Howard RF, Lloyd-Thomas A, Thomas M, Williams DG, Saul R, Bruce E, Peters J (2010) Nurse-controlled analgesia (NCA) following major surgery in 10,000 patients in a children's hospital. Paediatr Anaesth 20 (2): 126-34

Reference 12

Walker IA, Merry AF, Wilson IH, McHugh GA, O'Sullivan E, Thoms GM, Nuevo F, Whitaker DK, GO Project teams (2009) Global oximetry: an international anaesthesia quality improvement project. Anaesthesia 64 (10): 1051-60

Reference 13

Wrightson F, Soma M, Smith JH (2009) Anesthetic experience of 100 pediatric tracheostomies. Paediatr Anaesth 19 (7): 659-66

Reference 14

Leong L, Black AE (2009) The design of pediatric tracheal tubes. Paediatr Anaesth 19 Suppl 1 (): 38-45

Reference 15

Wellesley H, Chong WK, Segar P (2009) Who should obtain written consent for magnetic resonance imaging under general anesthesia?. Paediatr Anaesth 19 (10): 961-3

Reference 16

Ahmad N, Evans P, Lloyd-Thomas AR (2009) Anesthesia in children with mastocytosis--a case based review. Paediatr Anaesth 19 (2): 97-107

Reference 17

Walker IA (2009) Con: pediatric anesthesia training in developing countries is best achieved by out of country scholarships. Paediatr Anaesth 19 (1): 45-9

Reference 18

Standing JF, Howard RF, Johnson A, Savage I, Wong IC (2008) Population pharmacokinetics of oral diclofenac for acute pain in children. Br J Clin Pharmacol 66 (6): 846-53

Reference 19

Bingham RM, Proctor LT (2008) Airway management. Pediatr Clin North Am 55 (4): 873-86, ix-x

Reference 20

Walker SM (2008) Pain in children: recent advances and ongoing challenges. Br J Anaesth 101 (1): 101-10

Reference 21

Walker IA, Wilson IH (2008) Anaesthesia in developing countries--a risk for patients. Lancet 371 (9617): 968-9

Reference 22

Harban FM, Connor P, Crook R, Bingham R (2008) Cardiopulmonary bypass for surgical correction of congenital heart disease in children with sickle cell disease: a case series. Anaesthesia 63 (6): 648-51

Reference 23

Ahmad NS, Walker IA, Brew S (2008) Repair of sinus venosus defect in a patient with untreated vein of Galen aneurysmal malformation. Paediatr Anaesth 18 (6): 548-53

Reference 24

George MS, Sury MR (2008) Reversal of paradoxical excitement to diazepam sedation. Paediatr Anaesth 18 (6): 546-7

Reference 25

Sury MR, Smith JH (2008) Deep sedation and minimal anesthesia. Paediatr Anaesth 18 (1): 18-24

Reference 26

Taylor CJ, Derrick G, McEwan A, Haworth SG, Sury MR (2007) Risk of cardiac catheterization under anaesthesia in children with pulmonary hypertension. Br J Anaesth 98 (5): 657-61

Reference 27

Woodthorpe C, Trigg A, Alison G, Sury M (2007) Nurse led sedation for paediatric MRI: progress and issues. Paediatr Nurs 19 (2): 14-8

Reference 28

Thomas M, Woodhead G, Masood N, Howard R (2007) Motion sickness as a predictor of postoperative vomiting in children aged 1-16 years. Paediatr Anaesth 17 (1): 61-3

Reference 29

Solan K, Glaisyer H (2006) Raised intracranial pressure in a neonate presenting as stridor. Paediatr Anaesth 16 (8): 877-9

Reference 30

Whitelock DE, de Beer DA (2006) The use of filters with small infants. Respir Care Clin N Am 12 (2): 307-20

Reference 31

Sury MR, Fairweather K (2006) The effect of melatonin on sedation of children undergoing magnetic resonance imaging. Br J Anaesth 97 (2): 220-5

Reference 32

Sury MR, Scuplak S (2006) Water-filled garment warming of infants undergoing open abdominal or thoracic surgery. Pediatr Surg Int 22 (2): 182-5

Reference 33

Glaisyer H, Way C (2005) Neonatal pneumothorax--an unexpected perioperative complication. Paediatr Anaesth 15 (11): 997-1000

Reference 34

White MC, Walker IA, Jackson E, Thomas ML (2005) Impact of the European Working Time Directive on the training of paediatric anaesthetists. Anaesthesia 60 (9): 870-3

Reference 35

Sury MR, Harker H, Begent J, Chong WK (2005) The management of infants and children for painless imaging. Clin Radiol 60 (7): 731-41

Reference 36

Howard RF, Walker SM, Mota PM, Fitzgerald M (2005) The ontogeny of neuropathic pain: postnatal onset of mechanical allodynia in rat spared nerve injury (SNI) and chronic constriction injury (CCI) models. Pain 115 (3): 382-9

Reference 37

Glaisyer HR, Sury MR (2005) Recovery after anesthesia for short pediatric oncology procedures: propofol and remifentanil compared with propofol, nitrous oxide, and sevoflurane. Anesth Analg 100 (4): 959-63

Reference 38

Glaisyer HR, Yule C (2005) The Portex 'Soft Seal' single use laryngeal mask -- a preliminary study in pediatric anesthesia. Paediatr Anaesth 15 (2): 110-4

Reference 39

Sury MR, Harker H, Thomas ML (2005) Sevoflurane sedation in infants undergoing MRI: a preliminary report. Paediatr Anaesth 15 (1): 16-22

Reference 40

Jenkins JA, Facer EK (2004) Anesthetic management of a patient with myotonic dystrophy for a Nissen fundoplication and gastrostomy. Paediatr Anaesth 14 (8): 693-6

Reference 41

Bingham B (2003) Paediatric anaesthesia: past, present and future. Anaesthesia 58 (12): 1194-6

Reference 42

Mallory S, Yap LH, Jones BM, Bingham R (2004) Anaesthetic management in facial bipartition surgery: the experience of one centre. Anaesthesia 59 (1): 44-51

Reference 43

Williams DG, Howard RF (2003) Epidural analgesia in children. A survey of current opinions and practices amongst UK paediatric anaesthetists. Paediatr Anaesth 13 (9): 769-76

Reference 44

Howard RF (2003) Current status of pain management in children. JAMA 290 (18): 2464-9

Reference 45

De Beer D, Chambers N (2003) Double trouble: prolapsing epiglottis and unexpected dual pathology in an infant. Paediatr Anaesth 13 (5): 448-52

Reference 46

de Beer DA, Thomas ML (2003) Caudal additives in children--solutions or problems?. Br J Anaesth 90 (4): 487-98

Reference 47

De Beer DA, Williams DG, Mackersie A (2002) An unexpected difficult laryngoscopy. Paediatr Anaesth 12 (7): 645-8

Reference 48

Latoo MY, Oliver A, Roebuck D (2002) Anaesthetic management of hepatic artery chemoembolization in a paediatric patient. Paediatr Anaesth 12 (7): 629-31

Reference 49

Herod J, Denyer J, Goldman A, Howard R (2002) Epidermolysis bullosa in children: pathophysiology, anaesthesia and pain management. Paediatr Anaesth 12 (5): 388-97

Reference 50

Wongprasartsuk P, Stevens J (2002) Cerebral palsy and anaesthesia. Paediatr Anaesth 12 (4): 296-303

Reference 51

Harrison EA, Mackersie A, McEwan A, Facer E (2002) The sitting position for neurosurgery in children: a review of 16 years' experience. Br J Anaesth 88 (1): 12-7

Reference 52

Main E, Castle R, Stocks J, James I, Hatch D (2001) The influence of endotracheal tube leak on the assessment of respiratory function in ventilated children. Intensive Care Med 27 (11): 1788-97

Reference 53

Howard RF, Hatch DJ, Cole TJ, Fitzgerald M (2001) Inflammatory pain and hypersensitivity are selectively reversed by epidural bupivacaine and are developmentally regulated. Anesthesiology 95 (2): 421-7

Reference 54

Wootton MA, Lockie J (2001) Anaesthetic management of a child with a positive family history of malignant hyperthermia for posterior fossa surgery in the sitting position. Paediatr Anaesth 11 (4): 498-500

Reference 55

Tong JL, Thomas ML (2001) World Wide Web resources and the paediatric anaesthetist: surf's up. Paediatr Anaesth 11 (1): 19-27

Reference 56

Duce D, Glaisyer H, Sury M (2000) An evaluation of propofol combined with remifentanil: a new intravenous anaesthetic technique for short painful procedures in children. Paediatr Anaesth 10 (6): 689-90

Reference 57

Nixon MC (2000) The anaesthetic logbook--a survey. Anaesthesia 55 (11): 1076-80

Reference 58

MacIntyre PA, Samra G, Hatch DJ (2000) Preliminary experience with the Doppler ultrasound guided vascular access needle in paediatric patients. Paediatr Anaesth 10 (4): 361-5

Reference 59

Sacks MD, Marsh D (2000) Bilateral recurrent laryngeal nerve neuropraxia following laryngeal mask insertion: a rare cause of serious upper airway morbidity. Paediatr Anaesth 10 (4): 435-7

Reference 60

Sage FJ, Lloyd Thomas AR, Howard RF (2000) Paediatric lumbar epidurals: a comparison of 21-G and 23-G catheters in patients weighing less than 10 kg. Paediatr Anaesth 10 (3): 279-82