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A small girl, with blonde hair in pigtails and with a nasal tube, listens to two scientists talking about DNA

Marking Rare Disease Day 2023

7 Mar 2023, 11 a.m.

Rare Disease Day is a global event that aims to raise awareness and generate change for those living with rare diseases. At GOSH, many of our patients and families are part of the rare disease community and so this year we were delighted to mark the…

Staff working at cell and Gene therapy clean room at the ZCR

New commercial agreement for gene therapy at GOSH

16 Mar 2023, 9:57 a.m.

Great Ormond Street Hospital for Children (GOSH) and Leucid Bio have entered a new commercial agreement to manufacture a gene therapy product.

Sampler in a lab in the Zayed Centre for Research

Adeno-associated viruses implicated in disease in world-first

30 Mar 2023, 4 p.m.

A research team spanning GOSH and UCL has, for the first time, connected adeno-associated viruses with development of hepatitis in some children

Researchers sit around a coffee table, discussing and taking notes. A women in blue jeans and a green jumper, with square glasses speaks to the group

A return of the NIHR GOSH BRC academic training weekend

25 Apr 2023, 9 a.m.

The weekend is part of a programme of training opportunities that the NIHR GOSH BRC offers to the wider paediatric research community and aimed to support attendees as they transition to independent researchers.

Illustration of future digital tool to support personalised care for children

GOSH and Roche UK partnership using AI to bring personalised healthcare to children

16 May 2023, 10 a.m.

GOSH and Roche UK have partnered to harness the power of data by co-develop digital tools. This can uncover better ways to care for children and young people with rare and complex diseases.

A close up of a pippet and test tubes.

GOSH staff recognised in prestigious research prize

18 May 2023, noon

Four members of staff from GOSH and UCL GOS ICH have today been recognised by the Academy of Medical Sciences for their exceptional contributions to the advancement of biomedical and health science

3 nurses stand outside the Great Ormond Street Hospital entrance. Anna stands on the left wearing her blue nurses uniform with her brown hair up in a high ponytail. Waffa stands in the middle wearing a navy nurses uniform and clear rimmed glasses. Hannah stands on the right-hand side wearing a blue uniform and her blonde hair in a low ponytail

Transitioning clinical trials at GOSH

20 May 2023, 7 a.m.

At GOSH we run hundreds of clinical trials each year, many of which take place in our dedicated facility - the NIHR GOSH CRF. But how do we transition trials out of the facility into a new setting?

Blue stem cells with purple dots growing with tree like branches.

How 3D ‘bio-printing’ can shape mini-organs

9 Jun 2023, 4 p.m.

Scientists have shown for the first time how 3D printing can be achieved inside ‘mini-organs’ growing in hydrogels - controlling their shape, activity, and even forcing tissue to grow into ‘moulds’.

A young boy wears safety goggles, a white lab coat and very large blue protective gloves. He holds onto and looks down a mini-microscope while sat on a lime green chair.

Celebrating International Clinical Trials Day with our patients and families

21 Jun 2023, 11 a.m.

On 19 May we enjoyed welcoming patients, their families and GOSH staff, including GOSH nursery to the Lagoon to celebrate International Clinical Trials Day as well as the NIHR “Be Part of Research" campaign.

A young girl in a blue t-shirt is sitting down with her back to the camera, stretching sideways to shake the hand of a man in a white shirt who is bending down to meet her. She is smiling and so is he.

GOSH receives over £3.5m for research and innovation

28 Jun 2023, 11:31 a.m.

GOSH has been awarded over £3.5m by the NIHR for vital research and innovation equipment that will help to improve treatments for children

Four people stand in a line, smiling at the camera with their arms around each other. On the far left stands a nurse., Jan, wearing a blue uniform and black framed square glasses. She stands next to a Austin's Mum, Louise, who has a dark brown bob wearing jeans and a black jumper. Austin stands next to his mum, wearing a black hoodie and black trousers. Finally, Danielle, another nurse, stands on the far right with blonde hair in a ponytail and a blue nurses uniform

Unlocking the mystery of long-lasting cancer treatment

6 Jul 2023, 8 a.m.

Researchers from across GOSH, UCL GOS ICH and the Wellcome Sanger Institute have published new insights that explain why some children have a longer remission than others after having cutting-edge CAR T-cell therapy for leukaemia.

A close up photograph of multiple pippets and test tubes.

Global genomic collaboration improves lives and treatment for children with epilepsy

17 Aug 2023, 8 a.m.

An international research collaboration, including GOSH and our research partner UCL Institute of Child Health, has shown that a technique known as rapid genome sequencing can provide a diagnosis for 43 per cent of children with unexplained epilepsy.

A tree like structure made up of fluorescent blue, green and pink dots.

Steps forward in gene therapy for hearing loss linked to rare disease

29 Aug 2023, 3 p.m.

An international team led by researchers at GOSH, UCL and the NIHR GOSH BRC have developed in mice a gene therapy that significantly reduces the hearing loss associated with Norrie disease.

Photograph of a digital screen with brain imaging. Text on top reads '5 Years of Digital Innovation: Impact Report'

Over 300 innovative projects completed since the launch of GOSH DRIVE in 2018

25 Sep 2023, 1:09 p.m.

The Data Research, Innovation and Virtual Environments (DRIVE) unit at GOSH was launched five years ago. Our new report explains how this first-of-its-kind unit has led to improvements in research and innovation, and care for children and young people.

A crowd of people, focusing on 3 women in the middle distance, in conversation, smiling. In the foreground a woman wearing a headscarf looks down

A showcase of research

7 Sep 2023, 5:12 p.m.

This summer saw the return of the NIHR GOSH BRC showcase.

Aditi in a hospital room, sat on our hospital bed at GOSH. She wears a bright yellow top, and has a nasogastric (NG) feeding tube and bright pink glasses and a purple monster hat. She smiles just off camera.

GOSH patient first in the UK to receive improved kidney transplant

22 Sep 2023, 10 a.m.

Eight-year-old Aditi is the first child in the UK and on the NHS to be taken off immunosuppressants just one-month after kidney transplant at Great Ormond Street Hospital (GOSH).

Lab technicians working in a specialist GOSH laboratory, wearing white protective suits and masks and orange gloves.

GOSH receives new MHRA authorisation to manufacture viral vectors

1 Nov 2023, 5 p.m.

GOSH has been granted a Manufacturer's Authorisation Licence for the manufacture of viral vectors, which will accelerate Cell and gene therapies (CGT) clinical trials worldwide and expand the novel treatments that we can offer to our patients.

A young girl with light brown and orange long hair smiling. She has medals hanging from red, white and blue ribbon around her neck.

Clinical trial results give new hope for children with rare brain tumours

18 Nov 2023, 8 a.m.

Researchers who are searching for better treatments for an incredibly rare type of brain tumour have published successful results from the latest rounds of clinical trials.

Illustration of healthcare professional using a computer and a child with a cochlear implant. There are numbers leaving the computer that represent data.

GOSH to provide support for AI and Machine Learning as part of new paediatric HealthTech Research Centre

23 Nov 2023, 10 a.m.

GOSH will support the new Child and Young People’s HealthTech Research Centre (HRC), led by Sheffield Children’s Hospital, as leads for AI and Machine Learning.

A young boy smiles widely at the camera from a car seat. He's wearing a straw summer hat and summer clothes. In the background you can see a blurry picture of a little girl in another car seat

Reducing oxygen levels for children in intensive care will save lives

1 Dec 2023, 11:30 p.m.

A new landmark study led from GOSH has found that reducing oxygen levels for critically ill children on mechanical ventilators in intensive care could save lives

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