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Cellular benefits of gene therapy seen decades after treatment

16 Mar 2021, 4:54 p.m.

An international collaboration has shown the beneficial effects of gene therapy can be seen decades after the transplanted blood stem cells have been cleared by the body.

GOSH and UCL researchers receive funding to improve outcomes for children and young people with cancer

18 Mar 2021, 10 a.m.

Researchers at University College London and Great Ormond Street Hospital receive £1.7m of grants in new Cancer Research UK-Children with Cancer UK Innovation Awards.

Common inflammatory bowel disease treatment is linked to reduced COVID-19 antibody response

25 Mar 2021, 4:22 p.m.

New evidence indicates the commonly-prescribed inflammatory bowel disease (IBD) drug infliximab blunts the immune system to COVID-19 infection, potentially increasing the risk of reinfection.

MicroRNA from stem cells could be used to treat babies while still in the womb

29 Apr 2021, 3:11 p.m.

Scientists and doctors from GOSH and Toronto 'Sick Kids' have come together to take advantage of the regenerative properties of stem cells isolated from amniotic fluid.

International study finds gene therapy offers a potential cure to children born without an immune system

11 May 2021, 11:31 a.m.

An international team of researchers at GOSH and UCLA have developed a gene therapy that successfully treated 48 out of 50 children with a form of severe combined immunodeficiency

GOSH study reports most symptoms of severe COVID-19 in children are resolved after six months

24 May 2021, 11:30 p.m.

Scientists and doctors from GOSH and UCL GOS ICH have reported that, despite severe illness, most children who had PIMS-TS after contracting SARS-CoV-2 infection had their symptoms resolve after six months.

New insight into when CAR T is effective against childhood leukaemia

24 May 2021, 4 p.m.

Scientists studying the effectiveness of CAR T-cell therapies in children with leukaemia have discovered a small sub-set of T-cells that are likely to play a key role in whether the treatment is successful

Helping parents find answers after miscarriage

21 Jun 2021, 11:22 a.m.

A team at GOSH have developed a non-invasive imaging technique for the post-mortem imaging of babies who are miscarried or stillborn.

Alexia and Henrietta - patient survey.jpg

Learning from patients and families during a pandemic

21 Jun 2021, 11:38 a.m.

Researchers have worked with a patient support group to better understand the wide range of parenting experiences during the pandemic.

Origins of kidney cancers confirmed

23 Jun 2021, 10 a.m.

The origins of seven types of kidney cancer, including several rare subtypes, have been identified.

Gene therapy offers hope to children with rare and fatal brain diseases

29 Jun 2021, 10 a.m.

Scientists and doctors at UCL GOS ICH and GOSH have given hope of a gene therapy cure to children with a rare degenerative brain disorder called Dopamine Transporter Deficiency Syndrome (DTDS)

First lockdown sees rise in numbers of children swallowing small objects

28 Jul 2021, 4 p.m.

The number of children referred to Great Ormond Street Hospital for Children between March and September 2020 after swallowing a small object was more than double that recorded in the same period the year before, according to new research published today.

First findings from world’s largest study on long-COVID in children

2 Sep 2021, 9:28 a.m.

Up to one in seven children and young people may have symptoms of long-COVID 15 weeks later, suggest preliminary findings from GOSH and UCL ICH.

Crown Prince of Abu Dhabi meets families at the Zayed Centre for Research into Rare Disease in Children.

Crown Prince of Abu Dhabi meets clinicians and researchers at the Zayed Centre for Research into Rare Disease in Children

22 Sep 2021, 10 a.m.

We recently hosted His Highness Sheikh Mohamed bin Zayed Al Nahyan, Crown Prince of Abu Dhabi, the Secretary of State for Health Sajid Javid MP, and the Secretary of State for Education Minister Nadhim Zahawi MP at our Zayed Centre for Research.

Former GOSH patient Rhys pictured as an adult

UK’s first gene therapy baby celebrates 21st birthday

1 Oct 2021, 11 a.m.

The first child to be treated in the UK with gene therapy celebrates his 21st birthday this week, twenty years after having the pioneering treatment at Great Ormond Street Hospital for Children (GOSH).

Lucy smiles at the camera, with a heart balloon and heart cake in front of her.

New technique makes heart transplant possible for more children in need

18 Oct 2021, 1 p.m.

Ten-year old Lucy made history in 2020 as the oldest person in the world to receive a ‘mismatched heart’, thanks to a new technique developed by British Heart Foundation funded researchers at Great Ormond Street Hospital.

Cartoon image of blood cells, DNA and circulating viruses

Building our understanding of how children with rheumatic disease react to coronavirus infection

27 Oct 2021, 4 p.m.

A new study has shown that, despite having immune dysfunction and often being on immunosuppressive treatments, children with autoimmune rheumatic diseases have a favourable immune response to common coronavirus infections.

Rare disease genome sequencing uncovers new diagnoses for patients

15 Nov 2021, 2:08 p.m.

A world-first scientific study with major involvement from GOSH, published in the New England Journal of Medicine, has shown that whole genome sequencing (WGS) can uncover new diagnoses for people across the broadest range of rare diseases.

GOSH celebrates second anniversary of Zayed Centre for Research into Rare Disease in Children

4 Jan 2022, 2:04 a.m.

To celebrate its recent second birthday, we’re looking back at a remarkable two years at the Zayed Centre for Research into Rare Disease in Children.

A microscopic image of the mini stomachs.

Lab-grown stomachs help to shed light on COVID-19 symptoms in children

3 Dec 2021, 12:40 p.m.

For the first time, an international team of scientists and doctors have used these advances to develop a lab-grown model of the human stomach. This can be used to study how infections in humans impact the gastrointestinal system.