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Biomedical Research Centre news

New Drug Targets for Childhood Cancer Neuroblastoma Identified

8 Feb 2021, 12:13 p.m.

The largest single cell study to date of the childhood cancer, neuroblastoma, has answered important questions about the genesis of the disease. Researchers from Great Ormond Street Hospital (GOSH), the Wellcome Sanger Institute and their collaborat…

GOSH-led metformin trial dramatically reduces seizures for people with Tuberous Sclerosis

2 Feb 2021, 4:28 p.m.

A team of researchers led by UCL Great Ormond Street Institute of Child Health (ICH) and Great Ormond Street Hospital (GOSH) has found that metformin – a drug commonly used to treat Type 2 diabetes – can successfully reduce symptoms associated with …

Ancient gene mutation found as the cause of rare hereditary condition for GOSH patient

18 Jan 2021, 5:11 p.m.

UK scientists have found that a 7,000-year-old genetic mutation is responsible for a rare form of hereditary motor neuropathy (HMN).

Scientists build whole functioning thymus from human cells

22 Dec 2020, 4:24 p.m.

Researchers from two leading national organisations have rebuilt a human thymus using human stem cells and a bioengineered scaffold thanks to support from the NIHR GOSH Biomedical Research Centre (BRC). Their work, which has been published in Nature Commu

Leukaemia trial shows promise and complexity of genome-edited cell therapies

12 Dec 2020, 5:16 p.m.

A ‘one size fits all’ immune therapy developed at the UCL Great Ormond Street Institute of Child Health (ICH) could help to clear cancerous cells in children and adults who have exhausted all other treatment options for B-cell acute lymphoblastic leukaemi