Spyros Batzios

Dr Batzios sees referrals with a broad range of diagnoses. He undertakes general paediatric metabolic clinics, and he has full on-call duties.

His interests include but are not limited to:

• Lysosomal storage disorders
• Neurometabolic disorders
• Disorders related to lipid metabolism

Dr Batzios completed his medical school studies in Thessaloniki, Greece, where he also got his MSc (Medical Research Methodology – Basic research) and PhD focusing on the study of extracellular matrix molecules in patients with Mucopolysaccharidoses.

He completed his training in Paediatric Metabolic Medicine at GOSH.

Dr Batzios had always a strong interest in research. Since 2016 he has been the principal and sub investigator in multiple high intensity clinical trials related to the discovery of innovative treatments for patients with various Inborn Errors of Metabolism. His research continues today in MPSs, Pompe disease, Gangliosidosis, Urea Cycle disorders (Arginace deficiency, OTC), and lipid related disorders.

He has published widely scientific papers in peer reviewed medical journals.

He also maintains a keen interest in teaching and is involved in university teaching programmes as well as teaching in workshops in Paediatric Metabolic Medicine.

1. Spyros Batzios, Galit Tal, Andrew T. DiStasio, Yanyan Peng, Christiana Charalambous, Paola Nicolaides, Erik-Jan Kamsteeg, Stanley H. Korman, Hanna Mandel, Peter J. Steinbach, Ling Yi, Summer R. Fair, Mark E. Hester, Anthi Drousiotou, Stephen G. Kaler. Newly identified disorder of copper metabolism caused by variants in CTR1, a high-affinity copper transporter. Human Molecular Genetics
2. Okur I, Ezgu F, Giugliani R, Muschol N, Koehn A, Amartino H, Harmatz P, de Castro Lopez MJ, Couce ML, Lin SP, Batzios S, Cleary M, Solano M, Peters H, Lee J, Nestrasil I, Shaywitz AJ, Maricich SM, Kuca B, Kovalchin J, Zanelli E. Longitudinal Natural History of Pediatric Subjects Affected with Mucopolysaccharidosis IIIB. J Pediatr. 2022 Jun 13:S0022-3476(22)00538-8. doi: 10.1016/j.jpeds.2022.06.005. Epub ahead of print. PMID: 35709957.
3. Diaz GA, Schulze A, McNutt MC, Leão-Teles E, Merritt JL 2nd, Enns GM, Batzios S, Bannick A, Zori RT, Sloan LS, Potts SL, Bubb G, Quinn AG. Clinical effect and safety profile of pegzilarginase in patients with arginase 1 deficiency. J Inherit Metab Dis. 2021 Jul;44(4):847-856. doi: 10.1002/jimd.12343. Epub 2021 Jan 26. PMID: 33325055; PMCID: PMC8359196.
4. Pinto A, Ashmore C, Batzios S, Daly A, Dawson C, Dixon M, Evans S, Green D, Gribben J, Hunjan I, Jameson E, Newby C, Pierre G, Rajwal S, Robertson L, Santra S, Sharrard M, Vara R, White L, Wilcox G, Yilmaz O, MacDonald A. Dietary Management, Clinical Status and Outcome of Patients with Citrin Deficiency in the UK. Nutrients. 2020 Oct 29;12(11):3313. doi: 10.3390/nu12113313. PMID: 33137944; PMCID: PMC7693899.
5. Chinopoulos C, Batzios S, van den Heuvel LP, Rodenburg R, Smeets R, Waterham HR, Turkenburg M, Ruiter JP, Wanders RJA, Doczi J, Horvath G, Dobolyi A, Vargiami E, Wevers RA, Zafeiriou D. Mutated SUCLG1 causes mislocalization of SUCLG2 protein, morphological alterations of mitochondria and an early-onset severe neurometabolic disorder. Mol Genet Metab. 2019 Jan;126(1):43-52. doi: 10.1016/j.ymgme.2018.11.009. Epub 2018 Nov 16. PMID: 30470562.
6. Batzios SP, Zafeiriou DI, Papakonstantinou E. Extracellular matrix components: an intricate network of possible biomarkers for lysosomal storage disorders? FEBS Lett. 2013 Apr 17;587(8):1258-67. doi: 10.1016/j.febslet.2013.02.035. Epub 2013 Feb 26. PMID: 23454643.