https://www.gosh.nhs.uk/our-people/staff-z/hoong-wei-gan/
Hoong-Wei Gan
BMedSci (Hons) BMBS MSc PhD MRCPCH
Hoong-Wei is a consultant paediatric endocrinologist who qualified in medicine at the University of Nottingham Medical School (2006), paediatric endocrinology in Nottingham and London, and completed research degrees (MSc 2013, PhD 2020) at the UCL Great Ormond Street Institute of Child Health.
He is interested in the hormonal effects of brain tumours and their treatment, particularly on the hypothalamus and pituitary gland. He is Co-Chair of the British Society for Paediatric Endocrinology & Diabetes Special Interest Group in Hypothalamo-Pituitary Axis Tumours (HPAT) and coordinates the National HPAT Advisory Group. At GOSH, he helped set up the first collaborative, multidisciplinary long-term follow-up clinic for brain tumours survivors. He is departmental Co-Lead for Education and Training, and Education Lead for Digital Learning with the GOSH Learning Academy.
Hoong-Wei spends his free time baking, cooking and trying not to kill his plants!
Specialisms
- Neuroendocrine effects of brain tumours and their treatment
- Congenital hypothalamic and pituitary disorders
Research & Academic Interests
Hoong-Wei has research interests in the neuroendocrine effects of brain tumours and their treatment, particularly in long-term outcomes of brain tumour survivors. His MSc examined the long-term outcomes of survivors of optic pathway low-grade gliomas, whilst his PhD focussed on appetite-regulating hormones in hypothalamic obesity.
He is Deputy Chair of the National Paediatric Craniopharyngioma Guideline Development Group, and helped develop the first evidence-based guidelines for the management of this tumour. He is also member of the European Society of Paediatric Oncology (SIOP-E) Working Groups for craniopharyngioma and low-grade glioma, and the International Guideline Harmonisation Group for Late Effects of Childhood Cancer (IGHG) subgroup for growth hormone treatment in childhood cancer survivors.
Publications
Gan HW, Cerbone M, Dattani MT. Appetite- and Weight-Regulating Neuroendocrine Circuitry in Hypothalamic Obesity. Endocr Rev. 2024 May 7;45(3):309-342. doi: 10.1210/endrev/bnad033
Gan HW, Morillon P, Albanese A, Aquilina K, Chandler C, Chang YC, Drimtzias E, Farndon S, Jacques TS, Korbonits M, Kuczynski A, Limond J, Robinson L, Simmons I, Thomas N, Thomas S, Thorp N, Vargha-Khadem F, Warren D, Zebian B, Mallucci C, Spoudeas HA. National UK guidelines for the management of paediatric craniopharyngioma. Lancet Diabetes Endocrinol. 2023 Sep;11(9):694-706. doi: 10.1016/S2213-8587(23)00162-6
Mushtaq T, Ali SR, Boulos N, Boyle R, Cheetham T, Davies JH, Elder CJ, Gan HW, Hindmarsh PC, Katugampola H, Krone N, Salomon Estebanez M, Shenoy S, Tollerfield S, Wong SC, Regan F; Developed by the Paediatric Adrenal Insufficiency Group on behalf of the British Society for Paediatric Endocrinology and Diabetes (BSPED). Emergency and perioperative management of adrenal insufficiency in children and young people: British Society for Paediatric Endocrinology and Diabetes consensus guidance. Arch Dis Child. 2023 Apr 12:archdischild-2022-325156. doi: 10.1136/archdischild-2022-325156
Picariello S, Cerbone M, D'Arco F, Gan HW, O'Hare P, Aquilina K, Opocher E, Hargrave D, Spoudeas HA. A 40-Year Cohort Study of Evolving Hypothalamic Dysfunction in Infants and Young Children (<3 years) with Optic Pathway Gliomas. Cancers (Basel). 2022 Jan 31;14(3):747. doi: 10.3390/cancers14030747
Hage C, Gan HW, Ibba A, Patti G, Dattani M, Loche S, Maghnie M, Salvatori R. Advances in differential diagnosis and management of growth hormone deficiency in children. Nat Rev Endocrinol. 2021 Oct;17(10):608-624. doi: 10.1038/s41574-021-00539-5
Gan HW, Phipps K, Aquilina K, Gaze MN, Hayward R, Spoudeas HA. Neuroendocrine Morbidity After Pediatric Optic Gliomas: A Longitudinal Analysis of 166 Children Over 30 Years. J Clin Endocrinol Metab. 2015 Oct;100(10):3787-99. doi: 10.1210/jc.2015-2028