https://www.gosh.nhs.uk/our-people/staff-z/Tazeen_Ashraf/

Dr Tazeen Ashraf

This is a photo of Dr Tazeen Ashraf

Consultant in Clinical Genetics and Genomic Medicine

Dr Ashraf joined Great Ormond Street Hospital as a substantive Consultant in Clinical Genetics in 2020. Dr Ashraf works closely with Perinatal teams in the region and runs a joint Fetal-Genetics clinic at UCLH weekly. She is a member of the Clinical Genetics Society Council, the KBG Foundation Specialist Advisory Board, the Consanguinity Steering Group UK and was heavily involved in the consensus working group for prenatal testing and PGT for cancer predisposition genes.

Dr Ashraf trained at Barts and the London Medical School and undertook her postgraduate training in Paediatrics and then Clinical Genetics. She has worked at several institutions in London, Southampton and Bristol. She has a BMedSci (First Class Hons), University of London (2007), an MB BS (Hons), University of London (2008), MRCPCH, (2012), PGCert Clinical Education, King’s College London (2015), PGCert Interpretation and Clinical Application of Genomic Data, St George’s University (2017), RCPATH Certificate in Medical Genetics (2018)

Specialisms

Areas of Special Interests: Prenatal genetics, Pre-Implantation Genetic Testing (PGT) and Rare diseases

Research interests: KBG syndrome, Reproductive and Prenatal Genetics

Selected publications:

  • Prenatal and pre-implantation genetic testing for monogenic disorders for germline cancer susceptibility gene variants: UK joint consensus guidance. BJOG. 2023 Jun 19. doi: 10.1111/1471-0528.17571. Epub ahead of print. PMID: 37334763. Wafik M, Kilby MD, Kulkarni A; Cancer Genetics Group and Fetal Genomics Group for the British Society for Genetic Medicine.
  • PUF60-related developmental disorder: A case series and phenotypic analysis of 10 additional patients with monoallelic PUF60 variants. Am J Med Genet A. 2023 Oct;191(10):2610-2622. doi: 10.1002/ajmg.a.63313. Epub 2023 Jun 11. PMID: 37303278. Grimes H, Ansari M, Ashraf T, Cueto-González AM, Calder A, Day M, Fernandez Alvarez P, Foster A, Lahiri N, Repetto GM, Scurr I, Varghese V, Low KJ.
  • Missense variants in ANKRD11 cause KBG syndrome by impairment of stability or transcriptional activity of the encoded protein. Genet Med. 2022 Oct;24(10):2051-2064. doi: 10.1016/j.gim.2022.06.007. Epub 2022 Jul 14. Erratum in: Genet Med. 2023 Sep 1;:100962. PMID: 35833929.de Boer E, Ockeloen CW, Kampen RA, Hampstead JE, Dingemans AJM, Rots D, Lütje L, Ashraf T, Baker R, Barat-Houari M, Angle B, Chatron N, Denommé-Pichon AS, Devinsky O, Dubourg C, Elmslie F, Elloumi HZ, Faivre L, Fitzgerald-Butt S, Geneviève D, Goos JAC, Helm BM, Kini U, Lasa-Aranzasti A, Lesca G, Lynch SA, Mathijssen IMJ, McGowan R, Monaghan KG, Odent S, Pfundt R, Putoux A, van Reeuwijk J, Santen GWE, Sasaki E, Sorlin A, van der Spek PJ, Stegmann APA, Swagemakers SMA, Valenzuela I, Viora-Dupont E, Vitobello A, Ware SM, Wéber M, Gilissen C, Low KJ, Fisher SE, Vissers LELM, Wong MMK, Kleefstra T.
  • Feasibility of low-intensity psychological interventions for emotional and behavioural difficulties in children and young people with genetic conditions: a case series. The Cognitive Behaviour Therapist (2022), vol. 15, e59, page 1 of 15, Oct 22. doi:10.1017/S1754470X22000551. Ching BCF, Bennett SD, Rojas N, Heyman I, Liang H, Catanzano M, Coughtrey AE, Ashraf T, Jones WD, Male A, Shafran R.
  • Ear lobe creases: A novel phenotypic feature in KBG syndrome. Am J Med Genet A. 2022 May;188(5):1618-1622. doi: 10.1002/ajmg.a.62675. Epub 2022 Feb 17. PMID: 35175682.Ashraf T, Harrison M, Irving M.